If measured from beginning to end, the DNA in our cells is too long to fit into the cell's nucleus, explaining why it must be constantly folded and packaged. When it is time for cell division, and ...

Packing tightly the DNA at the wrong time can lead to severe consequences for the cell and for the organism – for example, uncontrolled DNA packing is associated with primary microcephaly.

In this way, retrotransposons add code to the human genome every time they move, which explains why 500,000 LINE-1 repeats now represent a "staggering" 20% of the human genome. These repeats drive ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs ...

From their data, the scientists realized that during cell division, DNA forms loops in two stages. First, it forms stable large loops, which then subdivide into smaller, short-lived nested loops ...

By enabling multigenerational tracking of DNA damage, the authors shine a light on how cellular heterogeneity and genome instability arise, one cell division at a time. Nature 642, 576-577 (2025) ...

In the case of DNA, if this overwinding is not dealt with, essential processes such as copying DNA and cell division grind to a halt. Fortunately, cells have an ingenious solution to carefully ...

"The changes to cell DNA that could revolutionize disease prevention." ScienceDaily. ScienceDaily, 21 August 2024. <www.sciencedaily.com / releases / 2024 / 08 / 240821221840.htm>.

To the point DNA packaging: DNA exists in different states in order to fulfill different functions in the cell nucleus. A research team has now discovered a molecular switch that controls the ...