The epigenetic modification 5-hydroxymethylcytosine (5hmC) plays a crucial role in the regulation of gene expression. Although some methods have been developed to detect 5hmC, direct genome-wide ...

Observations support all Omicron variants to significantly escape neutralising antibodies across a range of vaccination and/or convalescent responses. Potency of therapeutic monoclonal antibodies is ...

Once inside the cells and after aquation, it leads to the formation of CDDP–DNA adducts that interfere with DNA replication and transcription. Nonetheless, similar to many other anticancer drugs, CDDP ...

Studying ancient DNA from the Maya region has always been challenging because the tropical climate makes it hard to preserve genetic material. Despite these difficulties, the research team achieved a ...

This enhancement was accompanied by the upregulation of essential components in the lytic phase of EBV DNA replication, including a viral oncogene BARF1 (Hoebe et al, 2013), the BCL-2-like antagonists ...

Trading into the 2026 draft, Pius Suter as a sensible free agency target and a juggernaut mentality: Leaflets Where draft picks play matters, at least a little Goalies for the Maple Leafs to keep an ...

The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a critical need to discover more effective antivirals. While therapeutics for SARS-CoV-2 exist, ...

One challenge with selecting AAV mutant libraries for variants that alter virus production is the loss of genotype-phenotype linkages, which can occur under transfection conditions that favor ...

Ensuring that DNA replication occurs at the right stage of the cell cycle is of crucial importance in biology. In bacteria, DNA replication begins with the assembly of a DNA-protein complex called the ...

Lincoln, RI (02865) Today. Sunny to partly cloudy. High near 85F. Winds WNW at 10 to 15 mph..