In the DNA double helix, the two joined strands run in opposite directions, thus allowing base pairing between them, a feature that is essential for both replication and transcription of the genetic ...

It consists of multiple repair pathways, each focusing on a specific category of DNA lesion, and various checkpoint, signal-transduction, and effector systems connected with replication ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...

More information: Xing Kang et al, Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors, Cell (2025). DOI: 10.1016/j.cell.2025.04.012 Provided by Chinese ...

Mitochondrial deoxyribonucleic acid (mtDNA) plays a crucial role in energy production and abnormalities in mtDNA are linked to various diseases. However, its regulatory mechanism remains ...

Environmental mutagens including UV light can cause DNA breaks, and these breaks tend to occur more frequently in DNA replication and transcription intermediates. The bacterium Escherichia coli ...

A joint study revealing a new mechanism on DNA Replication Initiation, led by The University of Hong Kong (HKU), The Hong Kong University of Science and Technology (HKUST), and other institutions ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding, published ...

The G4-DNA structure can therefore be involved in both the enhanced and impairment of transcription in active neurons, based on their activity, to enable different memory states.

When these pathways are activated, DNA replication is suppressed at sites in the genome called origins; at the same time, the progression of DNA replication forks also slows down. Replication forks, ...