In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods ...

ORACLE, a powerful new tool that speeds up evolution, allowing scientists to design and improve proteins thousands of times ...

Discover the latest insights on RNA Polymerase I clinical trials, addressing ribosome biogenesis-dependent cancers. This comprehensive report discusses direct inhibitors, market opportunities, and ...

Improved understanding of how bacterial defense mechanisms operate may help scientists select phages with the best chance of ...

Evande, R., Rana, A., Biswas-Fiss, E.E. and Biswas, S.B. (2023) Protein-DNA Interactions Regulate Human Papillomavirus DNA Replication, Transcription, and Oncogenesis ...

TERRA R-loops interfere with semiconservative DNA replication, promoting telomere maintenance by a homology-directed repair (HDR) mechanism known as break-induced replication (BIR), which ensures ...

We highlight the diverse ways by which chromatin dynamics is controlled during transcription, DNA replication, and repair. Recent technological developments have promoted discoveries in this area, to ...

Researchers have now uncovered the role of mitochondrial transcription elongation factor in maintaining the balance between mtDNA transcription and replication.

This suggests that the absence of TEFM disrupts the proper balance between the replication and transcription processes, which has consequences on mtDNA maintenance and expression. Another significant ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...