As DNA polymerase extends the leading strand, Okazaki fragments form on the lagging strand. However, gaps remain after RNA primer removal. At this stage, DNA ligase bridges these gaps, securing a ...

Just like the government uses an Aadhaar number to uniquely identify an individual for social security purposes, a person’s DNA fingerprint can be used for biological purposes. This is why DNA ...

The agreement includes licenses for the HiFi DNA Polymerase, HiTemp Reverse Transcriptase ... increasing commercial adoption of the dsRNA ligase, and the build-out of our ECO Synthesis ...

Using cryogenic electron microscopy (cryo-EM), researchers revealed how conformational changes in the viral DNA polymerase alter the virus’s susceptibility to drugs. The new findings further the ...

Why PCR Is Relevant to STI Testing Polymerase chain reaction, and related techniques like ligase chain reaction, are growing in importance for STI testing. That's because these techniques can directly ...

Nudler and coworkers found that during this transcription process, RNA polymerase also finds DNA lesions, and then serves as a platform for the assembly of a DNA repair machine called nucleotide ...

RNA polymerase motors down the DNA chain, reading the code of DNA "letters" as it transcribes instructions into RNA molecules, which then direct protein building. Nudler and coworkers found that ...

In addition to DNA polymerase, DNA ligase, and topoisomerases, there are many other DNA modifying enzymes that play critical roles in maintaining the genetic stability of an organism. For example, ...

Lesions are first detected, then they are processed and/or excised by a nuclease. Lastly, a polymerase synthesizes new DNA to replace the missing nucleotides, and a ligase seals the resulting nick ...

These domains are a polymerase domain, to fill in nucleotide gaps with a preference for ribonucleotide addition; a phosphoesterase domain, to generate a 3′-hydroxyl DNA end; and the ligase domain, to ...