Using cryo-microscopy, researchers present a high-resolution structure of monkeypox virus DNA polymerase holoenzyme, a complex that plays a key role in the genome replication process of the virus.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 4 (January 24, 2017), pp. 675-680 (6 pages) The eukaryotic genome is primarily replicated by two DNA ...

They determined the holoenzyme structure in complex with DNA using cryo-electron microscopy at the global resolution of ~2.8 Å. According to the findings, the holoenzyme possesses an architecture ...

The DNA polymerase III holoenzyme, which carries out chromosomal DNA replication in Escherichia coli, comprises three main parts: the catalytic core, responsible for DNA synthesis; the doughnut ...

In bacterial cells, DNA polymerase III is known to make about 2,000 of these mistakes every time it copies a cell’s genetic material. To maintain genome integrity, the bulk of misplaced ...

In bacterial cells, DNA polymerase III is known to make about 2,000 of these mistakes every time it copies a cell's genetic material.

RNA polymerase (Pol) III has a noncanonical role of viral DNA sensing in the innate immune system. This polymerase transcribes viral genomes to produce RNAs that lead to induction of type I ...

The DNA damage response (DDR) pathway coordinates the identification, signaling, and repair of DNA damage caused by endogenous or exogenous factors and regulates cell-cycle progression with DNA repair ...

Fifty of 395 children with stage III or IV WT enrolled on Children's Oncology Group trial AREN0533 had banked pretreatment serum, urine, and tumor available. Next-generation sequencing was used to ...

Researchers reveal DNA repair mechanism Date: May 21, 2023 Source: NYU Langone Health / NYU Grossman School of Medicine Summary: A new study adds to an emerging, radically new picture of how ...