genome-wide CRISPR approach to identify novel factors involved in uracil repair with potential clinical interest. The authors designed elegant experiments to confirm the METTL3 works through genomic ...

This manuscript reports important findings that the methyltransferase METTL3 is involved in the repair of abasic sites and uracil in DNA, mediating resistance to floxuridine-driven cytotoxicity. The ...

Here, the authors show that loss of DNA methylation during development allows Cdx2 to activate target genes.

Genome-wide methylation profiling is available at our genomics facility ... For the analysis we need good quality DNA in a concentration of 50 ng/ul in a minimum volume of 20-30 ul. Illumina ...

Stanford Medicine researchers sifted through thousands of single nucleotide mutations in DNA to identify fewer than 400 that are functionally associated with inherited cancer risk.

Klara EBITA Margin: 10.4%, despite a 9% decrease in net sales. Ambea AB (FRA:6MA) achieved a 7% increase in net sales for Q4 2024, driven by increased occupancy and new acquisitions. The company ...

Learning about your genetics and ancestry is easier than ever. All you need to do is choose from the many DNA ancestry tests available online, receive your kit and send back the required DNA samples.

However, genome-wide epigenetic changes that are associated with short-term hypoxia exposure remain largely unknown. We collected a series of DNA samples from 15 participants of European ancestry ...

The aim of this study was to investigate the role of DNA methylation in pSS by analysing multiple tissues from patients and controls. Methods Genome-wide DNA methylation profiles were generated using ...

Breast cancer (BC) is a heterogeneous disease characterized by several molecular subtypes that differ in clinical behaviors and response to current therapies (Zardavas et al., 2015). Approximately 75% ...