The latter include internal or capping loops, noncanonical base pairings, and regions involving conformational ... For the samplings of the nucleotide orientations, each nucleotide in the RNA/DNA ...

This is where DNA and RNA epigenetics comes in: a series of mechanisms that act as "markers" on genes, to control their activity without modifying the DNA or RNA sequence itself. Until now, DNA and ...

This research will be of broad interest to RNA molecular biologists and biochemists ... of randomly fragmented human genomic DNA (8). We showed that these two ribozymes shared essentially the same ...

RNA’s Surprising Role in DNA Repair New insights could lead to improved treatments for cancer and other diseases. Francesca Storici and her research team discovered a surprising role for RNA in DNA ...

The target-binding loop comprises two key regions that base-pair with the top and bottom strands of the target DNA ... strand pairings and suggesting a key role for bridge RNA-core interactions ...

Present in both DNA and RNA sequences, a G-quadruplex (GQ) is a structure of four guanine bases attached in a planar array. These arrays, known as G-tetrad, are connected via Hoogsteen base pairings.

Google DeepMind has expanded its AlphaFold AI system to not only predict the structure of proteins, but also to model how proteins interact with other cell structures, including DNA, RNA ...

Yet for the past 25 years, Aldevron, a manufacturer of DNA, RNA, and proteins, has grown and thrived here in the Northern Great Plains, developing products that support innovation in cell and gene ...

CRISPR technology that targets RNA and uses the Cas13 enzyme is less established ... and mismatches that resulted in G–U wobble pairings were better tolerated than other single-base mismatches. The ...

Summary: Researchers developed a deep learning model, TIGER, that accurately predicts on- and off-target activity of RNA-targeting CRISPR ... that result in G–U wobble pairings are better tolerated ...

Nucleic acids, deoxyribonucleic acid (DNA ... Crick A-T and G-C base pairs. On the other hand, the non-canonical structures include G-quadruplexes, i-motifs, triplexes and cruciform hairpins, etc. are ...