Consequently, NTD-seq enables the direct deamination of cytosine to uracil by A3Am, which is sequenced as thymine, whereas 5mC, once oxidized to 5moC by nTET, resists deamination and is sequenced ...

As the 2-hydroxy-group is present in the biologically important pyrimidines (cytosine, uracil, thymine), it is important to have authentic 2-hydroxypyrimidine available for the interpretation of ...

Here we focus on read mapping, which is challenging because un-methylated cytosines are transformed to uracil during bisulfite treatment and to thymine during the subsequent polymerase chain reaction, ...

The anionic complexes of formic acid with uracil and thymine reveal broad features in photoelectron spectroscopy (PES) experiments with maxima at 1.7 and 1.1 eV, respectively. The results of quantum ...

Purpose: The basic concepts of pharmacogenetics, pharmacogenetic study approaches, factors to consider when applying pharmacogenetic discoveries to patient care, and potential roles for ...

One is CYP2C9*2 (a cytosine to thymine [C to T] change at nucleotide position 430, abbreviated 430C> T), which encodes an amino acid substitution (arginine to cysteine change at codon 144 ...

OBJECTIVE To assess whether the size of the cytosine-thymine-guanine (CTG) expansion mutation in myotonic dystrophy predicts progression of conduction system disease and cardiac events. DESIGN ...

The enzymes that transfer a methyl group to C5 of cytosine within specific sequences (C5 Mtases) deaminate the target cytosine to uracil if the methyl donor S-adenosylmethionine (SAM) is omitted from ...

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