Now, over 100 years after the complement system was first described, researchers at Mass General Brigham have discovered that a protein known as granzyme K (GZMK) drives tissue damage and ...

The Complement group, headed by Prof. Seppo Meri, has for long had an interest in sorting out how and why the complement system contributes to disease pathogenesis, how the system is controlled and ...

A component of the complement system promotes tumor growth by activating myeloid-derived suppressor cells. Figure 1: Multiple pro-inflammatory mediators in the tumor microenvironment increase the ...

Earlier this year, Apellis Pharma became the first company to claim FDA approval for a drug to treat the condition, Syfovre (pegcetacoplan), which also targets the complement system. Syfovre needs ...

These mechanisms include antimicrobial peptides called defensins, phagocytosis, and the complement system. Vertebrates such as humans have even more sophisticated defense mechanisms. The immune ...

JENA, Germany, March 07, 2025 (GLOBE NEWSWIRE) -- InflaRx N.V. (Nasdaq: IFRX), a biopharmaceutical company pioneering anti-inflammatory therapeutics targeting the complement system, today announced ...

Despite evidence of an involvement of inflammatory and immunological mechanisms in the pathogenesis of Alzheimer's disease, the therapeutic benefits of anti-inflammatory agents are still unclear.

which inhibitor will be the next to harness the complement system for the development of groundbreaking therapies? With assets in nephrology, ophthalmology, neurodegeneration, and inflammation all ...

Equibase has begun the process of developing a racehorse ratings system, reports the Daily Racing ... “We certainly see this ...

GT Metabolic Solutions' 50mm magnet of the MagDI System has received clearance from the US Food and Drug Administration (FDA) ...