They include: Greater than 10% of clonal bone marrow plasma cells on bone biopsy or extramedullary plasmacytoma Presence of one or more of the previous CRAB features or the following myeloma ...

This composite flow cytometric panel illustrates the bone marrow of a newly diagnosed primary plasma cell leukemia patient demonstrating CD38 +, λ-a-restricted, CD20-plasma cells.

Multiple myeloma (MM) is a bone marrow cancer caused by clonal proliferation of plasma cells, and it is classified as a plasma cell dyscrasia. Over the last 20 years, there has been a dramatic ...

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of immunoglobulins, also called antibodies. But in this disease, light chains misfold ...

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of immunoglobulins, also called antibodies. But in this disease, light chains misfold ...

Diverse stem cells can respond to different stresses, so the dominance of a handful of clones makes the whole system more fragile.” This work is published in Nature in the article ...

So multiple myeloma is a disease of clonal plasma cells and we are very fortunate to have several approved therapeutic options, often using combination to obtain very deep responses. Proteasome ...

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of immunoglobulins, also called antibodies. But in this disease, light chains misfold ...

Some of them become white blood cells, which are an important part of your body’s immune system. Plasma cells are a type of white blood cell. Normally, they make antibodies -- proteins to help ...