Results from a new clinical trial suggest that a high-fiber plant-based diet could benefit patients at risk for developing ...

Results from a new clinical trial suggest that a high-fiber plant-based diet could benefit patients at risk of developing ...

Multiple myeloma (MM) is a bone marrow cancer caused by clonal proliferation of plasma cells, and it is classified as a plasma cell dyscrasia. Over the last 20 years, there has been a dramatic ...

Diagnosis also required -- and still does -- the presence of at least 10% infiltration of clonal plasma cells on bone marrow examination or a biopsy-proven bony or extramedullary plasmacytoma.

“Talquetamab is a first-in-class bispecific antibody that targets an orphan molecule, GPRC5D that is aberrantly expressed on clonal plasma cells as a single agent,” Bahlis said. “It reported ...

So multiple myeloma is a disease of clonal plasma cells and we are very fortunate to have several approved therapeutic options, often using combination to obtain very deep responses. Proteasome ...

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of immunoglobulins, also called antibodies. But in this disease, light chains misfold ...

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of immunoglobulins, also called antibodies. But in this disease, light chains misfold ...

characterized by extensive infiltration of clonal plasma cells in the bone marrow, for which a proportion of patients suffer poor outcome and exhibit no obvious symptoms in the early stages.

a serious disease in which light chain proteins are overproduced in clonal plasma cells and then misfold, aggregate, and form amyloid deposits in vital organs – including in the heart.

Based on specific cytogenetic alterations that occur in clonal plasma cells during MM progression, myeloma cells may develop resistance to standard MM treatments such as proteasome inhibitors and ...