Characterizing clonal evolution in blood cancers like acute myeloid leukemia (AML) is critical for understanding their mutational histories and how cell populations change during disease development.

The authors discuss both the practical and theoretical limitations of the clonal model of cancer evolution and suggest ways to enhance its relevance and accuracy. Cancer cells are driven by the ...

TI-CH remodeled the tumor immune microenvironment and accelerated tumor organoid growth, findings that support a role for an aging-related hematologic clonal proliferation in cancer evolution.

The study revealed the mechanisms of the clonal evolution of the tumor and its transformation into a more aggressive form of leukemia at the level of individual subclones. It has also been shown ...

A review examines the prevailing theory of cancer evolution. The authors highlight both practical and theoretical limitations of the clonal model of cancer evolution and propose areas for ...