Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally and remains a major public health ...

This patent describes a novel therapeutic strategy involving conjugate compounds that integrate a poly(ADP-ribose) polymerase (PARP) inhibitor moiety with a disease-targeting ligand, offering a ...

Although C-C chemokine receptor 4 (CCR4) has been shown to mediate the recruitment of T cells to inflamed tissues, its role in atherosclerosis is unclear. Here, we show that genetic deletion of CCR4 ...

Diabetic kidney disease (DKD) is a severe complication of diabetes, characterized by chronic inflammation and fibrosis. Tang Shen Ping Decoction (TSPD), a traditional Chinese medicine formulation, has ...

CheMo4METPANC: Combination chemotherapy (gemcitabine and nab-paclitaxel), chemokine (C-X-C) motif receptor 4 inhibitor (motixafortide), and immune checkpoint blockade (cemiplimab) in metastatic ...

About ABBV-514 ABBV-514 is an investigational anti-chemokine C-C motif receptor 8 (CCR8) antibody that is being investigated for the treatment of relapsed non-small cell lung cancer (NSCLC) and head ...

Other targets under investigation include C-C motif chemokine receptor 4, which is expressed in skin memory Th2 cells, and Bruton's tyrosine kinase, but data are not yet available.

APC, antigen-presenting cell; CCR2, C-C motif chemokine receptor 2; CCR5, C-C chemokine receptor 5; CSF1R, colony-stimulating factor-1 receptor; CTL, cytotoxic T-lymphocyte; CTLA-4, cytotoxic ...

Methods: The on-going prospective study (NCT05519735) enrolls patients with acute ST-elevation MI followed by complete reperfusion and multimodal imaging with C-X-C motif chemokine receptor 4 ...