This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Although C-C chemokine receptor 4 (CCR4) has been shown to mediate the recruitment ... 40 For analysis of atherosclerotic lesions in the aortic root, 5 consecutive sections (10 μm thickness), spanning ...

In the coadministration strategy, the chemokine-expressing construct was ... of the established solid tumors [89] CCL21 + mitomycin C Breast cancer MCF-7 cells Augmentation of mitomycin C ...

Regarding the specific migration of Th17 cells, IL-17A has a synergistic effect with TNFα to promote CCL20 (also known as macrophage inflammatory protein 2 alpha (MIP3α)) expression leading to the ...

Normally, neutrophils recognize chemokines including the bacterial product N-formyl-methionyl-leucyl-phenylalanine (fMLP), complement 5a (C5a), and lipid molecules Leukotriene B4 (LTB4) and C-X-C ...

CCL2: Chemokine (C-C motif)Ligand 2, SCF1:Stem Cell Factor 1, uPAR: Urokinase Plasminogen Activator Receptor, IL-8: Interleukin-8, IL-6: Interleukin-6, bFGF: Basic fibroblast growth factor, SASP: ...

Methods: Patients with active SjD (N=190) were randomised (1:1:1:1) to receive placebo or ianalumab (5, 50, or 300 mg ... B-cell maturation antigen (BCMA), C-X-C motif chemokine ligand 13 (CXCL13) and ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...

23 In a normal immune response, after infection by an intracellular pathogen, macrophages are activated by pattern-recognition receptors ... and the overall 5-year survival was 50% and 59% ...

Purpose: The basic concepts of pharmacogenetics, pharmacogenetic study approaches, factors to consider when applying pharmacogenetic discoveries to patient care, and potential roles for ...