NIH’s SMaHT Network will chart trillions of somatic mutations to reveal how our DNA changes over a lifetime. In a nutshell ...

CHK1 inhibitors release the brakes on cell-cycle arrest, rendering the DNA-damaged ecDNA-containing cancer cells vulnerable to apoptosis. 6 Efforts to monitor ecDNA levels noninvasively in blood ...

To address this gap, the study leveraged 64,000 fully synthetic DNA sequences to dissect the design principles of cell-state specific enhancers during differentiation of blood stem cells to seven ...

Their findings, which were published March 7 in Science, one of world’s leading scientific journals, not only reveal new details about how secondary DNA structures like G4s can impede DNA replication, ...

AI-designed DNA controls genes in healthy mammalian cells for first time Powerful and precise new way of turning genes on or off in specific types of cells only ...

Cell & Microbiology; May 22, 2025 The GIST. Ancient DNA used to ... Ancient DNA analysis of Borrelia recurrentis reveals it diverged from its tick-borne ancestor B. duttonii 6,000–4,000 years ...

Human and chimpanzee neural progenitor cells and cortical organoids were analyzed to assess enhancer activity and cell proliferation.. Genome editing was employed to generate mouse models ...