At 22, Daniel Cressy is making history as Louisiana’s first sickle cell gene therapy patient. The treatment could be a cure ...

Nature Reviews Molecular Cell Biology 10, 178–191 (2009). Kalab, P., Weis, K. et al. Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts.

Mammalian cells are tricky evolution hosts. They grow slowly, contain large genomes, and regulate protein behavior through unpredictable “post-translational modifications”—diverse chemical changes ...

More information: Md Noor Akhtar et al, Hominini-specific regulation of the cell cycle by stop codon readthrough of FEM1B, Journal of Cell Science (2024). DOI: 10.1242/jcs.261921 ...

Hoechst 33342 is one of the few live-cell DNA stains used in cell cycle analysis. However, this dye requires UV-light excitation, and many laboratory flow cytometers are equipped only with a 488 ...

Results: Only the sequence of paclitaxel followed by gefitinib in A549, H1975 and PC-9 cells produced synergistic effects in all of the drug concentrations. Exposure to paclitaxel resulted in an ...

Today, because of work conducted in model systems (yeast, worms, flies), cancer and normal mammalian cell lines, and rodents and higher mammals we have a detailed understanding of the conserved ...

The correct sequence of events is key During cell division, it is important that the many individual steps always occur in exactly the same order. If this does not happen, it results in malformations.

Consistent with previously published studies in other cell types, erlotinib resulted in G1 cell cycle arrest and docetaxel in G2-M arrest. On-going studies to investigate the mechanism for the ...

They applied a relatively new tool, the fluorescent ubiquitination-based cell-cycle indicator (FUCCI), to cultured mouse neurons to reveal those that re-engaged the cell cycle. At any given time, ...