Every time a eukaryotic cell divides, it faces a monumental challenge: It must carefully duplicate and divide its genetic ...
New research shows that cancer cells don’t just grow; they adapt when stressed. When squeezed inside tissues, they transform ...
Another protein central to this process is NuMA, which is essential for spindle pole organisation. Normally, NuMA gathers at ...
Plasticity in cancer cells describes their inherent ability to undergo alterations and turn certain features on and off at different times. This flex | Cancer ...
Cell migration in confined environments leads to nuclear envelope rupture, chromatin leakage and genomic instability. This ...
A mixture of DNA and proteins—known as "chromatin"—sits inside every cell nucleus as a jumbled puddle of genetic information. As cells prepare to divide during mitosis, the chromatin is condensed into ...
Pressure from surrounding tissues activates invasive programs in cancer cells. This mechanical stress rewires epigenetic regulation. Cancer cells are notoriously adaptable, capable of shifting their ...
Before a chain of amino acids can become an active and useful protein, it must be processed and folded into the appropriate ...
Telomere damage drives T cell exhaustion. Antioxidants restored their cancer-fighting strength in mice. Tumor environments place heavy stress on immune cells that fight cancer. Limited oxygen, ...
The unfolded protein response (UPR) is a protective pathway that helps cells manage stress during protein production. Cancer cells exploit this ...
New research published in Immunity by researchers at the University of Pittsburgh found that, in mice, the toxic tumor environment causes mitochondria to generate reactive oxygen species (ROS) that ...
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