Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

Taking a cue from nature, the researchers showed they could all but eliminate off-target gene activation by designing weak transcription factors that cooperatively assemble. Bioengineers can ...

The latest insights into transcription factors provide a deeper understanding of the disease's progression and potential therapeutic interventions. Transcription factors are critical proteins that ...

Transcription factors affect a cell’s transcription patterns, regulating gene expression. In the case of T cells, Peng’s research shows that the transcription factors Tcf1 and Lef1 activate ...

Flare Therapeutics has launched with $82 million in series A financing to discover small-molecule drugs that target transcription factors implicated in cancer. The life science venture capital ...