Taking a cue from nature, the researchers showed they could all but eliminate off-target gene activation by designing weak transcription factors that cooperatively assemble. Bioengineers can ...

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

The latest insights into transcription factors provide a deeper understanding of the disease's progression and potential therapeutic interventions. Transcription factors are critical proteins that ...

The researchers' results reveal new patterns and preferences in how certain transcription factors interact with each other—also known as "motifs." In this study, the researchers estimate that ...

Flare Therapeutics has launched with $82 million in series A financing to discover small-molecule drugs that target transcription factors implicated in cancer. The life science venture capital ...

Researchers resolved human transcription factor (TF) regulation Date: February 9, 2022 Source: University of Helsinki Summary: A research team introduces a new large-scale study on human ...

Transcription factors affect a cell’s transcription patterns, regulating gene expression. In the case of T cells, Peng’s research shows that the transcription factors Tcf1 and Lef1 activate ...

Michael Erb, a chemical biologist at Scripps Research and coauthor on the paper, tells C&EN that transcription factors were previously considered undruggable because they “don’t have the types ...

"This collaboration will accelerate the expansion of our capabilities, enabling us to develop treatments for transcription factors implicated in indications with high unmet needs,” Rob Sims ...

"Our study provides the community with a comprehensive resource for investigating HNF4A and HNF1A gene targets in pancreatic beta cells and liver cells. By identifying key genes regulated by these ...