CRISPR-Cas systems are prokaryotic immune systems that confer resistance to foreign genetic elements such as plasmids and phages. CRISPR-Cas systems have been exploited for targeted genome editing ...

CRISPR base editors enable precise DNA changes but often cause off-target edits. Here, authors engineer two Sdd7 variants that minimize bystander and off-target mutations and show enhanced ...

Isotopes stadium drafts six new menu items for the first week of July. On July 1, fans can try three new taco specials. For ...

The sarcin−ricin domain is a universal element of the RNA from the large ribosomal subunit. The domain is part of the binding site for elongation factors and is specifically cleaved by the toxins ...

The base lesion 8-oxoguanine is formed readily by oxidation of DNA, potentially leading to G → T transversion mutations. Despite the apparent similarity of 8-oxoguanine-cytosine base pairs to normal ...