This crucial event in regulation of C3b promulgation on self surfaces is essential for protection of host tissues from complement-mediated damage. Building on previous indications that FH19–20 ...

Here we provide insight into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target, complement fragment C3b. FH interacted with ...

C3b binds to the surface of pathogens ... MAC is the cytolytic endproduct of the complement cascade; it forms a transmembrane channel, which causes osmotic lysis of the target cell. Kupffer cells and ...

15 Ribbon representation of the structure of complement C3b, as proposed by Janssen et al., 24 shows the interface region between the macroglobulin 1 domain (MG1) (light blue) and the thioester ...

CR1 is expressed on blood cells and microglia. As a receptor for the complement components C3b and C4b, CR1 helps regulate activation of the complement cascade and promotes phagocytosis of immune ...

Significant reductions in proteinuria, estimated glomerular filtration rate stability of the C3/C3b inhibitor were also ...

But would the approach also work in humans? To test this out, the researchers assessed levels of C1q and also C3b—an activated complement protein further down the cascade—in symptomatic and ...

One of its most powerful defense mechanisms is the complement system-a group of proteins that patrols our body, ever vigilant for signs of infection or injury. Now, over 100 years after the ...

SAN DIEGO — The investigational drug pegcetacoplan, a C3/C3b inhibitor ... are characterized by excessive deposits of the complement protein C3c; however, no treatments are available that ...

Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing: the first line of defense ...