eLife29d
Ocular biomarker profiling after complement factor I gene therapy in geographic atrophy secondary to age-related macular degeneration
This correlated with a marked post-treatment reduction in VH concentration of the FB breakdown product Ba and Ba:FB ratio, but minimal changes in C3a and C3b/iC3b levels. Variable concordance in ...
eLife29d
Ocular biomarker profiling after complement factor I gene therapy in geographic atrophy secondary to age-related macular degeneration
Modulation of complement AP and CP biomarkers by PPY988 delivery. Fold-changes (y-axis) in complement biomarker [FI, C3, FH, FB, C1q, Ba, C3a, C3b/iC3b, C4b, Ba:FB, C3a:C3, C3b/iC3b:C3] concentrations ...
The EMBO Journal29d
Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. While pancreatic beta-cell proliferation has ...
The EMBO Journal1mon
A bipartite bacterial virulence factor targets the complement system and neutrophil activation
The C-terminal fragment functions as a cysteine protease with a unique proteolytic activity and structure, which degrades several components of the complement system, such as C3 and C3b. Murine ...
Frontiers4y
Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H
C3b, iC3b, C3c and C3d are proteolytically generated fragments of human complement protein C3; VBS, Veronal-buffered saline; GVB, VBS containing 0.1% gelatin; HBS-P, HEPES-buffered saline containing ...
Frontiers7y
Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma
Protection of human cells against unwanted complement activation is achieved by complement factor H (FH), the major regulator of the alternative pathway. FH is an abundant plasma glycoprotein that ...