This crucial event in regulation of C3b promulgation on self surfaces is essential for protection of host tissues from complement-mediated damage. Building on previous indications that FH19–20 ...

Here we provide insight into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target, complement fragment C3b. FH interacted with ...

CR1 is expressed on blood cells and microglia. As a receptor for the complement components C3b and C4b, CR1 helps regulate activation of the complement cascade and promotes phagocytosis of immune ...

known as the ‘early’ events of complement activation. C3 convertase is bound covalently to the pathogen. C3 is cleaved to generate C3b, which mediates inflammation. C3b targets the pathogen ...

But would the approach also work in humans? To test this out, the researchers assessed levels of C1q and also C3b—an activated complement protein further down the cascade—in symptomatic and ...

The oral presentation, “Complement Factor I (CFI ... engineer a diverse library of enhanced CFI proteases that degrade C3b and/or C4b. Administration of the degraders resulted in improved ...

Empaveli is a complement inhibitor that binds to complement protein C3 and its activation fragment C3b. The Food and Drug Administration (FDA) has approved Empaveli™ (pegcetacoplan) for the ...