Complement forms an ancient innate immune defense. Gros and colleagues provide new insight into the interactions between complement convertase C3b and its regulator factor H and with the ...

The recent resolution of the long-awaited structures of the central components of the complement system — C3 and factor B — has finally revealed the molecular details of complement activation.

The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...

A collaborative team from Penn Medicine and Penn Engineering has uncovered the mathematical principles behind a ...

A collaborative team from the School of Engineering and Applied Science and the Perelman School of Medicine have unraveled the mathematics of a 500-million-year-old protein network that acts like the ...

C3b is a recognizable ligand for circulating macrophages, which bind to the subunit through the CR1 receptor and engulf the entity. The other subunit resulting from C3 cleavage is C3a, an ...

The researchers used neurodegeneration mouse models to test the effects of boosting Nptx2 levels or blocking complement protein in cells. In one of these mice models, a lack of Nptx2 was tied to ...

NM3086 blocked the deposition of C3b via AP, a marker of extravascul Phase I Clinical Trial in healthy subjects shows that NM3086 was safe and well tolerated at all doses (0.1 to 20 mg/kg) in six ...

One of its most powerful defense mechanisms is the complement system-a group of proteins that patrols our body, ever vigilant for signs of infection or injury. Skip to content. Menu.

Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing: the first line of defense ...