The structure of complement protein C3 reveals a large, modular protein consisting of 13 domains with a buried thioester moiety. Proteolytic activation of C3 into C3b induces conformational ...
For all complement-activating antibodies, C3b deposition on the surface of K. pneumoniae caused activation of complement-mediated phagocytosis and elimination by human neutrophils. Antibody ...
A) Complement is activated trough three pathways leading to C3b opsonization, release of anaphylatoxins (C5a) and formation of membrane attack complexes (MAC). Factor H (FH) regulates complement at ...