Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

More information: Francesca Chandler et al, Molecular glues that inhibit deubiquitylase activity and inflammatory signaling, Nature Structural & Molecular Biology (2025). DOI: 10.1038/s41594-025 ...

A team of researchers based in Japan has revealed the molecular mechanisms underpinning the process for small EVs (sEVs), which they said could have implications for developing better cancer ...

Division of Applied RI, Korea Institute of Radiological & Medical Sciences (KIRAMS), 75 Nowon-ro, Nowon-gu, Seoul 01812, Republic of Korea University of Science and Technology (UST), 217, Gajeong-ro, ...

The following steps were applied: (1) parsing CIF files into molecular format, (2 ... There are plenty of techniques for substituent or ligand features that are geometry based. (47) The most common ...

1515.T Nittetsu Mining Co., Ltd.

Ireland-based building materials firm Kingspan has signed a supply agreement with Hydnum Steel for green steel as part of its push to lower emissions across its operations and products. The UK and ...