This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis ...

To develop a covalent modifier for the amyloid-forming protein β-2-microglobulin (magenta), researchers used a nanobody (teal ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Research is very much part of Barbara Malheiros' DNA. As part of her PhD research, she placed DNA on the surface of tiny ...

A new paper describes how scientists used the tool to identify an important role for TRIM24 in mediating telomere repair after cells divide.

Each time a cell divides, a small section of each chromosome's protective cap - the telomere - is worn away. Most cells use ...

Researchers have developed a new tool to understand how cancer cells repair their telomeres, offering insights that could ...

Hair loss is one of the most common hair problems that many people struggle with. But when trying to identify the reasons, most look at it with tunnel vision, fixating only on scalp issues or haircare ...

Brazilian researchers have found that the brain protein hevin can reverse cognitive decline in mice, offering a new avenue for Alzheimer’s research that bypasses the long-targeted beta-amyloid plaques ...

Scientists have discovered that a molecule known for defending animal immune systems called itaconate also plays a powerful role in plants. Researchers showed that itaconate not only exists in ...