Suspecting that autophagy might promote the use of HR over error-prone repair pathways, the research team investigated its effect on gene editing. When autophagy was triggered—either by nutrient ...

Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson's disease protein by Doshisha University edited by Sadie Harley, reviewed by Robert Egan Editors' notes ...

Anlotinib inhibited the migration and invasion of osteosarcoma cells but promoted autophagy and increased ATG5 expression. Furthermore, the decreases in invasion and migration induced by anlotinib ...

Cold plunges for 7 days can trigger autophagy and cellular repair, possibly slowing aging and improving health, according to a new uOttawa-led study.

Enhanced levels of Beclin1 and ATG5 would act to facilitate macroautophagy and the degradation of misfolded proteins. Once the misfolded proteins are degraded via autophagy, GRP78 re-associates with ...

However, knocking out other essential autophagy genes such as ATG13 and FIP200 did not affect GLUT1 sorting. These findings suggest that ATG5 participates in the function of the Retromer in a ...

Figure 5: Canonical autophagy does not affect sorting of the retromer cargo GLUT1. A,B. HCM quantification of GLUT1 (immunostaining of endogenous protein) puncta/cell in in Huh7 WT, Huh7 ATG13-KO, ...

Autophagy declines with age. Some drugs that are being studied for their effect on aging, most notably rapamycin, increase the process.

The vast majority of autophagy studies have been done on animals and microorganisms: yeast, mice, and worms. This body of research is associated with promising results: For example, in one study ...

Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons. Nature Aging, 2024; DOI: 10.1038/s43587-023-00548-1 ...

Autophagy is a natural process in which your body breaks down and cleans out damaged cells. It is triggered by fasting and has been promoted for weight loss and longevity, although there is no ...