Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including Mycobacterium tuberculosis ...

106). Effector caspases (such as caspase 3) function primarily to cause the morphological features of apoptosis. Specifically, activation of caspase 3 leads to the breakdown of several ...

New in vivo evidence confirms that tumor-expressed Fas ligand impairs immune responses to cancer by inducing apoptosis of anti-tumor immune effector cells. A recent report demonstrated that murine ...

Natural killer (NK) cells can reduce the number of activated CD8+ T cells by induction of apoptosis ... as well as other immune effector cell–based therapies, may cause a complication that ...

However, the factors influencing the transcriptomes and effector functions of MAIT cells ... Annexin V staining was performed with the PE Annexin V Apoptosis Detection Kit (BD Biosciences) following ...

– Jakafi ® (ruxolitinib) net revenues of $773 million (+11% Y/Y) in the fourth quarter 2024 and $2.8 billion (+8% Y/Y) for ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

What is Known About the Estrogen Deficiency of Menopause & Specific Autoimmune Diseases It is known that many natural, pathological and therapeutic conditions can change serum estrogen levels ...

Phenotypic characterization revealed enhanced infiltration of memory CD4+ T cells and effector CD4+ T cells in the primary tumor, tumor-draining lymph node, and DCC-driven metastasis site. A robust ...

Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. (C.W., W.X., S.J., Y.W., J ...