The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila ...

Novartis has finally given up on iscalimab after deciding that the anti-CD40 antibody is not worth pursuing in Sjögren’s syndrome. On a fourth-quarter earnings call with the media this morning ...

Sanofi's RSV antibody Beyfortus, after smashing blockbuster sales threshold, still has room to grow in US: execs By Fraiser Kansteiner Jan 30, 2025 11:45am ...

If the antibody interacts with a key part of a microbial structure, it can block infection. Antibodies (like their targets) come in a dizzying array — which means that some antibodies block their ...

Confo Therapeutics, a leader in the discovery of novel medicines targeting G-protein coupled receptors (GPCRs), today announced a publication in Nature Communications demonstrating the world’s ...

In the publication, Confo further demonstrated the first-ever cryo-EM structure of a complex between an antibody-based agonist, a GPCR and the G-proteins. This was enabled by Confo’s patent ...

In the chemical world, the tiny hyphen in antibody-drug conjugates—or ADCs, as they’re commonly known—does a lot more work than the perfunctory punctuation suggests. That hyphen stands for ...

A CCP test may be necessary if a doctor thinks you have rheumatoid arthritis. Here’s what else is necessary to make a diagnosis and what the results mean.

Background: Most pts receiving immune checkpoint inhibitors do not respond to treatment or relapse. FS222 is a novel affinity optimized, tetravalent bispecific PD-L1/CD137 antibody. FS222’s structure ...