Background Non-invasive biomarkers with biological rationale are needed for identifying patients with progressive metabolic dysfunction-associated steatohepatitis (MASH). Objective To test the ...

Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cardiac fibrosis contributes to adverse ...

aDivision of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Chonnam National University, Gwangju, South Korea bDivision ...

Background Interferon (IFN)-stimulated gene 15 (ISG15) is a downstream molecule of the IFN pathways central to many cellular processes. ISG15 mainly exerts its function through a post-translational ...

Fibrosis of the lungs is often a silent disease until it's too late. By the time patients are diagnosed, the scarring of their lung tissue is already advanced, and current treatments offer little more ...

Liver fibrosis represents a universal pathological endpoint in chronic hepatic disorders, in which hepatic macrophages play a pivotal role through dynamic phenotypic modulation. These versatile immune ...

Women had overall higher rates of the primary composite outcome (death, myocardial infarction, or heart failure hospitalization) than men during a median follow-up of 3.7 years. HealthDay News — For ...

Acute myocardial infarction and acute kidney injury are life-threatening conditions caused by ischemia, resulting from reduced or blocked blood flow to organs. Although early restoration of blood flow ...

Researchers conducted a phase 3b open-label trial at multiple sites in Australia and the European Union to assess the effect of elexacaftor-tezacaftor-ivacaftor, an approved medication for cystic ...