Most people won’t get kidney problems due to ankylosing spondylitis. But it may not be as rare as once thought. Research shows kidney disease happens in 8%-35% of people with ankylosing spondylitis.

If you have ankylosing spondylitis, ... Amyloidosis. In rare situations, amyloid protein can collect in organs like the kidneys, liver, and heart. They can’t work right because of this.

Amyloidosis is a group of conditions that cause an abnormal protein called amyloid to build up in the body. Treatment depends on the type of amyloidosis but may include medications and organ ...

Drugs that treat a similar plasma cell disease, multiple myeloma, can sometimes be effective in people with AL amyloidosis. By far, the most important of these drugs is daratumumab (Darzalex), a ...

Recent insights into processes involved in fibrillogenesis have opened new therapeutic avenues for amyloidosis. Julian Gillmore and Philip Hawkins update us on the development of drugs to ...

The double-blind, placebo-controlled, time-to-event AFFIRM-AL trial (ClinicalTrials.gov Identifier: NCT04973137) assessed the safety and efficacy of birtamimab in 207 newly diagnosed, treatment ...

Alnylam Pharmaceuticals has revealed new interim data from its Phase I trial of nucresiran, a ribonucleic acid interference (RNAi) therapeutic for transthyretin (ATTR) amyloidosis treatment. The ...

DEAR MAYO CLINIC: My dad was diagnosed with cardiac amyloidosis shortly after his 70th birthday. It’s difficult to pronounce let alone understand. What is cardiac amyloidosis? Am I at risk ...

Prothena has buried birtamimab for the second time. A phase 3 trial of the anti-amyloid antibody in the rare disease AL amyloidosis missed its primary endpoint, prompting the biotech to end ...

CARLSBAD, Calif., March 10, 2025--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that Ionis and AstraZeneca’s WAINZUA (eplontersen) has been approved in the European Union (EU) for ...

Intellia Announces Positive Two-Year Follow-Up Data from Ongoing Phase 1 Study of Nexiguran Ziclumeran (nex-z), in Patients with Hereditary Transthyretin (ATTR) Amyloidosis with Polyneuropathy at ...

Spondylitis refers to inflammatory conditions affecting the spine, which can lead to severe back pain, stiffness, and other complications. It primarily affects the spine and sacroiliac joints but ...