Leveraging novel microscopy techniques, researchers were actually able to measure amyloid fibril beta-sheet assemblies in real time. Specifically, researchers had to design a new imaging tool that ...

Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is ...

For example, Aβ42 can grow and decay in ways that preserve the underlying structure; sometimes there’s growth where the peptides just pile on, but the underlying beta-sheet orientations don’t change.

Amyloid-beta (A-beta) aggregates are tangles of proteins most notably associated with neurodegenerative diseases like Alzheimer's. Despite its constant stint in the limelight, however, researchers ...

Similarly, Aβ42 can decay as peptides leave, while the beta-sheet structure remains unchanged. They also found that Aβ42’s beta sheets can reorganize and change orientations without any immediate ...

Chemists will gather at the first rippled sheet symposium on March 17. The conversation has come a long way in just a few years, said Jevgenij. “In 2019 there were not only no crystal structures, ...

Since islet amyloid polypeptide is produced with insulin, as a result of common regulatory promoter sequences in the beta-cell–specific islet amyloid polypeptide and insulin genes, 28,29 the ...

Study: Β-Amyloid Deposits in Young COVID Patients. Image Credit: Kateryna Kon / Shutterstock.com *Important notice: Preprints with The Lancet publishes preliminary scientific reports that are not ...

Leqembi and Kisunla don’t just reduce amyloid plaques that are implicated in Alzheimer’s disease. According to new research, the drugs boost levels of a healthy form of amyloid beta (Aβ42 ...

Alzheimer’s disease fact sheet. (2023). ... Delivery of the Brainshuttle amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans.