The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

N-terminal sequencing targets the amino-terminal (N-terminal) end of a protein or peptide, which corresponds to the first ... results—such as when peptides lack fragmentation or exhibit signal ...

This segment turned out to be an 18-amino-acid sequence, which the team termed Exosome Binding Peptide (EBP). The team found that “addition of EBP to an unrelated protein directed secretion on ...

We used Molecular Evolutionary Genetics Analysis (MEGA) software, version 7.0.26, to construct phylogenetic trees on the basis of nucleotide and amino ... and the signal peptide is highlighted ...

We further explored the potential synergistic actions of FGF21 with the incretin glucagon-like peptide-1 (GLP-1 ... The clones with strong signal were selected for sequencing. Fc-FGF21 (L98R, S167H, ...

Rtc5 is N-myristoylated, and this modification is required for its localization to the vacuolar membrane In contrast to the vacuolar localization of C-terminally tagged Rtc5, N-terminally tagged Rtc5 ...

Proteolysis refers to breakdown of proteins into smaller polypeptides or amino acids. For example, removal of N-terminal methionine, a signal peptide, after translation leads to conversion of an ...

The characteristic current signatures of the α-synuclein peptide ... learning model for signal processing. We further demonstrate that this framework can quantify α-synuclein peptides at picomolar ...

(Photo credit: Bang Oland/Dreamstime) BNP is a peptide (a short chain of amino acids ... When your blood vessels get the signal from BNP, it tells them to open up more to lower blood pressure ...

Peptides are amino acids − the body's building blocks of protein. Josh Redd, NMD, the founder of RedRiver Health and Wellness and author of "The Truth About Low Thyroid," says peptides ...

Each protein or peptide consists of a linear sequence of amino acids. The protein primary structure conventionally begins at the amino-terminal (N) end and continues until the carboxyl-terminal (C ...