A cone snail toxin known to affect both insects and fish inspired Weizmann Institute scientists to develop a new way of finding molecular targets. By combining artificial intelligence with ...
The toxin is post-translationally proteolyzed to form a 1,285 amino acid di-chain molecule in which the two chains, ~50,000 M r and ~100,000 M r, remain linked by a disulfide bond 1. The protein ...
Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the ...
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