Taken together, these data indicate that POLG mutations induced astrocytic mitophagy failure by regulating the AKT/mTOR/AMPK/ULK1 signaling pathway. Nicotinamide Riboside and Metformin Treatment ...
High levels of active TBK1, however, negatively regulate AMPK, thus creating a negative feedback loop that can negatively affect autophagic flux. 3) Mitophagy: During PINK1-PARKIN-mediated mitophagy, ...
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The problem of microplastics (MPs) pollution has caused many health risks to residents ...
Effects of salt supplementation in uninephrectomized KK-Ay mice: Examining the potential of a diabetic kidney disease model.
This important study addresses the idea that defective lysosomal clearance might be causal to renal dysfunction in cystinosis. With mostly solid data, the authors observe that restoring expression of ...
This useful study partially succeeds in providing solid evidence in support of the therapeutic potential of the plant-derived compound eugenol for ameliorating symptoms associated with STZ-induced ...
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...
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