This and related inhibitors will not only be useful as tools to decipher the roles of the individual components of the spliceosome but may also serve as therapeutics. Using small molecules or ...

A new study found that aged neurons have defects in key proteins that make them vulnerable to molecular stress and neurodegenerative damage.

Well-established industry leader whose oncology expertise and transactions record has led to multiple approved therapeutic ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

Nature Structural & Molecular Biology is an academic journal publishing research articles, reviews, news and commentaries in structural biology and molecular biology, with an emphasis on papers ...

The spliceosome modulating properties of spliceostatins and synthetic derivatives opened the door for understanding the underlying spliceosome mechanism as well as the development of new therapies ...

Center for Synaptic Neuroscience and Technology (NSYN@UniGe), Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi ...

Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Healthcare Hospital, Beijing, China Objective: Lymph node ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Nuclear factor erythroid 2-related factor 2 ...