Romancing the Spliceosome to Fight Spinal Muscular Atrophy. Author: Kathryn J. Swoboda, M.D. Author Info & Affiliations. Published October 30, 2014. N Engl J Med 2014; 371: 1752-1754.

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The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") -- and about 150 proteins, involved in different stages of ...

Think of the spliceosome as an old Transformers robot — it has individual pieces that operate independently but can also come together to form a larger structure. Sometimes, such as in the case of ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The spliceosome cuts out unnecessary sequences of freshly transcribed RNA called introns and joins together the remaining sections to form messenger RNA (mRNA).

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The spliceosome undergoes multiple structural and compositional rearrangements, including extensive changes in its RNA–RNA network 3,4. In complex A, the U1 and U2 snRNAs base pair with the 5 ...

Spliceosome assembly in yeast extracts also could occur by interaction of the U1 snRNP with the pre-mRNA, followed by a tetra-snRNP joining to form a functionally identical particle. (Reprinted with ...

The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout ...