In the Gates Foundation’s final chapter, it is doubling down on its wager that health can engender prosperity. That proposition must now contend with the mixed macroeconomic evidence.

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi ...

An 11-year-old girl with eczema was evaluated for chest pain and arm pain. Imaging showed multiple bone and liver lesions. The erythrocyte sedimentation rate was higher than 130 mm per hour. A diag ...

A previously healthy 44-year-old man presented with a 4-day history of an itchy rash and a 2-day history of fever and malaise. A pleomorphic eruption of papules and pustules of different sizes and ...

Idiopathic normal-pressure hydrocephalus is a neurologic disorder characterized by impaired gait, balance, cognition, and ...

In this phase 3, multinational, randomized, double-blind trial, we examined the safety and efficacy of once-daily orforglipron at doses of 6 mg, 12 mg, or 36 mg, as compared with placebo (assigned in ...

Tobacco use kills more than 7 million people worldwide each year, including 1.3 million who die from the effects of exposure to secondhand smoke.1 As a major contributor to cancer, cardiovascular ...

There is an urgent need for low- and middle-income countries to ensure equitable, affordable, and sustained access to tobacco-cessation medications at scale.

Christopher Duggan is the director of the Center for Nutrition at Boston Children’s Hospital, a professor of pediatrics at Harvard Medical School, and a professor in the Departments of Nutrition and ...

Hypertrophic cardiomyopathy (HCM) is a complex, heterogeneous disorder that directly affects only the heart. It is characterized by hypertrophy of any portion of the left ventricular wall, frequently ...

The author describes the scientific foundations of a clinical trial of a first-in-class small-molecule estrogen receptor degrader to treat patients with metastatic breast cancer.