Larger studies looking at the benefits and harms of anti-TNF compared with conventional treatment for children with active Crohn's disease are needed. Among the important outcomes to be included are ...

Due to a lack of robust evidence, we could not determine the benefits and unwanted effects of hospital networks (organised trauma systems) or individual hospitals (designated trauma centres) that are ...

Large studies are needed to see if targeted therapies work in the different types of IIM. As IIM is rare, this would best be done by many centres working together internationally.

We found nine studies involving a total of 689 women with stress urinary incontinence. Nine studies compared vaginal lasers to either sham or lubricant, and one study compared vaginal lasers to ...

- Corticosteroids may decrease transient inflammatory reaction events associated with antibiotic treatment of leptospirosis infection, although the certainty of this evidence is very uncertain.

Palivizumab, when given through the veins or into a muscle (systemically), reduces hospitalisations due to respiratory syncytial virus (RSV) and reduces respiratory problems later on (chest wheezing), ...

Transcranial laser therapy (low-level light therapy applied to the head) does not reduce the number of people who die or have moderate to severe disability at 90 days after ischaemic stroke (where ...

Dysmenorrhoea is a common gynaecological problem consisting of painful cramps accompanying menstruation, which in the absence of any underlying abnormality is known as primary dysmenorrhoea. Research ...

Cochrane Interactive Learning is our comprehensive course on how to conduct a systematic review. Equip yourself, or your staff and students, with the skills to conduct systematic reviews through ...

Subclinical hypothyroidism is a condition where some laboratory findings point at a thyroid gland not working properly. Patients with subclinical hypothyroidism may have vague, non-specific symptoms ...

Gestational diabetes (GDM) affects 3% to 6% of all pregnancies. Women are often intensively managed with increased obstetric monitoring, dietary regulation, and insulin. However, there has been no ...

Topical silver treatments and silver dressings are increasingly used for the local treatment of contaminated or infected wounds, however, there is a lack of clarity regarding the evidence for their ...