Background Pregnant women with antiphospholipid antibodies and/or lupus have higher rates of adverse pregnancy outcomes (APOs), such as fetal loss and preterm birth due to severe preeclampsia (PE) or ...

Background Discoid lupus erythematosus (DLE) is one of the LE-specific skin diseases on the scalp, and some cases induce scarring alopecia. In systemic LE (SLE), variable nail changes not specific to ...

Background Systemic Lupus Erythematosus (SLE) is a prototypic, systemic autoimmune disease that can affect many organs. Current treatment of SLE is largely empirical, while the existing ...

Background Zetomipzomib is a first-in-class selective inhibitor of the immunoproteasome that offers anti-inflammatory properties without significant immunosuppression. 1 2 Methods The MISSION study is ...

Background Cellular immune responses are phenotypically and functionally perturbed in patients with lupus nephritis (LN), leading to severe renal tissue inflammation. Although multiple gene expression ...

Background Recent advances in the treatment of systemic lupus erythematosus (SLE) have focused on inducing specific immune tolerance to avoid complications from the long-term use of immunosuppressive ...

Background Systemic lupus erythematosus (SLE) is about 10 times more common among women than men. This sex bias was previously attributed to sex hormones. However, while sex hormones are abnormal in ...

Objectives This study aimed to investigate hemostatic variables in pregnant patients with Systemic Lupus Erythematosus (SLE) in relation to preeclampsia (PE), antiphospholipid antibody (aPL) status ...

Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare immune-mediated neurologic disorder that targets the peripheral nerves and nerve roots which can cause progressive ...

Objective Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) symptoms, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research on ...

Background Loss of self-tolerance and generation of numerous autoantibodies is a hallmark of systemic lupus erythematosus (SLE). Historically, testing for anti-nuclear antibodies (ANA) has been used ...

Background Immunoglobulin gamma-3 subclass, also called the immunoglobulin gamma 3 chain C (IGHG3), normally comprises 5%–8% of all IgG in humans. The salivary IGHG3 was increased in Korean patients ...