Structural and computational approaches uncover the molecular basis for dimerization, open-closed conformational transitions, and the dynamic behavior of the human angiotensin-I converting enzyme ...

In this important work, the authors present a new transformer-based neural network designed to isolate and quantify higher-order epistasis in protein sequences. They provide solid evidence that higher ...

A combination of cryogenic electron microscopy and molecular simulations has been used to study the structure and dynamics of an enzyme called ACE.

This work, combining behavioural genetics and calcium imaging, provides evidence for a form of learning in Drosophila that derives solely from direct or (optogenetically induced) phantom experience of ...

Stimulation of the A13 brain region restores motor function in Parkinson's disease mouse models by alleviating bradykinesia and akinesia.

The objects that migrants carry with them are tethers to the lives they have left behind.

Peer reviewers judge the validity and quality of new research. These judgements would ideally be impartial, but some reviewers may give a more favourable review if they are cited in the article ...

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States ...

The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.

Our understanding of the molecular pathogenesis of LAMA2 -related muscular dystrophy ( LAMA2 -MD) requires improving. Here, we report the phenotype, neuropathology, and transcriptomics data (scRNA-seq ...

Complementing previous work (Namiki et al, 2018), this study provides an important resource for the Drosophila community as it reports 500 lines targeting descending neurons (DN), in addition to ...

This study offers a valuable theoretical framework for quantifying molecular transport across interfaces between coexisting liquid phases, emphasizing interfacial resistance as a central factor ...