LSU, Ole Miss and college football
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Predicting LSU QB Garrett Nussmeier's Ole Miss stat line
LSU needs a big day from quarterback Garrett Nussmeier. We took a shot at predicting his state line for the top-15-ranked matchup in Week 5.
LSU running back Caden Durham, who injured his ankle last week against SE Louisiana, is doubtful for Saturday's game against Ole Miss, sources told ESPN.
Preview the Sept. 27 matchup between the Ole Miss Rebels and LSU Tigers with predictions, odds, over/under, spread, betting lines and more.
1don MSN
LSU vs. Ole Miss prediction, pick, odds, spread: No. 4 Tigers face stiff SEC test at No. 13 Rebels
The complexion of Saturday's showdown between No. 4 LSU and No. 13 Ole Miss looks far different than originally anticipated, thanks to an unexpected quarterback development for the Rebels. Division II transfer Trinidad Chambliss has burst onto the scene for Ole Miss amid the injury-related absence of starter Austin Simmons.
The LSU Tigers thought they'd be close to full strength entering its top-15 showdown with the Ole Miss Rebels this week, but a late curveball won't help their efforts.
Lane Kiffin and Co. will get a transfer wideout back in Week 5, on pace to make debut against the Bayou Bengals.
Offense Ranking: 21st Defense Ranking: 5th Strength of Schedule: 2nd. Through the first four games of the 2025 season, LSU is
Find single game tickets to the Ole Miss Rebels vs. LSU Tigers college football Week 5 matchup on Saturday, September 27, 2025.
A win over LSU would likely push Ole Miss back into the top-10 since their 24-17 loss to Florida last November. The FanDuel Sportsbook lists the Rebels as -1.5 home favorites (-112, meaning a $100 bet nets a $189.29 payout) as of Friday morning.
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