Her2/neu expression was evaluated by immunohistochemistry (IHC), real-time PCR and flow cytometry, while c-erbB2 gene amplification was assessed using fluorescent in situ hybridisation (FISH).

HER2/neu (HER2) and cyclin E are important prognostic indicators in breast cancer. As both are involved in cell cycle regulation we analyzed whether there was a direct interaction between the two.

Value of Serum Human Epidermal Growth Factor Receptor 2 (HER2)/neu Testing for Early Prediction of Response to HER2/neu-Directed Therapies Is Still an Open One and Deserves Further Study in Large ...

Generation of HER2-specific T-cell immunity could (1) target immunogenic and biologically relevant proteins such as HER2 in IBC, (2) result in immunogenic eradication of HER2+ tumor cells, and (3) ...

In late 2019, trastuzumab deruxtecan was approved for the treatment of metastatic HER2/neu-positive breast cancer based on a phase two single arm trial that showed an extremely high response rate ...

A study published by Caris showed that certain tumor types had very low or no HER2 overexpression, which has implications for biomarker testing strategies.

A subset analysis of 36 patients with stage IIIC/IV disease showed both a PFS benefit with the anti-HER2 approach, as well as an improvement in OS (31.9 vs 21.1 months; HR 0.44, 90% CI 0.22-0.88 ...

Roche is stepping up the defense of its critical HER2 franchise, committing $70 million in upfront and near-term payments to secure global rights to Zion Pharma’s early-phase treatment of brain ...