Radiation damage remains the principal limitation in achieving higher resolution in cryo-electron microscopy (cryo-EM), despite advances in cryoprotection and low-dose imaging. Researchers have ...

High-resolution cryo-electron microscopy makes it possible to study complex enzymatic processes in detail. With this method, a research team of the University of Potsdam and Humboldt-Universität ...

The more we can increase the time resolution on cryo-EM, the more details we can glimpse, whether it’s the functioning of myosins in muscle tissue or inside cells, the folding of proteins, or ...

Advantages Works with top cryo-EM cameras for single-particle analysis: Automate the capture of low-dose images on the K3, K2, BioContinuum, BioQuantum K3, GIF Quantum LS, and OneView cameras ...

Michigan State University. "Researchers use cryo-EM to identify what makes bacteria strong." ScienceDaily. ScienceDaily, 24 October 2024. <www.sciencedaily.com / releases / 2024 / 10 ...

Cryo-electron microscopy (cryo-EM) has revolutionalized our understanding of the intricate molecular machinery that governs life. It has elucidated the three-dimensional (3D) structure of biological ...

Cryo-EM resolves γ-secretase complexed with APP-C99, Aβ46, Aβ49, and Aβ43. During processing, an α-helix unwinds by one turn, while a three-residue β-strand positions it for the next cut. This ...

Now, using cryo-electron microscopy, researchers at the University of Tokyo determined the spatial structure of the SpCas9–M-MLV RTΔRNaseH–pegRNA–target DNA complex in multiple states.

Elsa Cryo-Transfer Workstation. Tutorial on how to load a cryo-sample, recover it, as well as dry the Elsa cryo-transfer workstation. Video Credit: Gatan, Inc.

The researchers determined cryo-EM structures for the frog and pig GnRHR–Gq complexes at resolutions of 2.67 Å and 3.18 Å, respectively.