The Buffalo Bills host the New Orleans Saints this weekend in what appears to be a lopsided matchup, at least on paper. The Bills are among the NFL’s elite, sitting at 3-0 with the top scoring offense in the league.

On Friday, head coach Sean McDermott and the Bills officially announced via X that Oliver and Milano are declared out against the Saints. That’s two big losses, with the linebacker racking up nine tackles, one sack, one tackle for loss, one quarterback hit and one pressure through two games.

This isn't the week for Spencer Rattler to throw 40 times, but the Saints passing offense must still make plays. Breaking down their Bills matchup:

Manzano is taking the Chargers so seriously, he ranked Jim Harbaugh's club at No. 2 overall behind only the defending Super Bowl champion Philadelphia Eagles. The Tampa Bay Buccaneers, San Francisco 49ers and Indianapolis Colts followed No. 3 Buffalo in that order.

The Buffalo Bills are ruling out two key defensive players heading into Week 4 against the New Orleans Saints.

Buffalo has improved to a 3-0 start to the 2025 season, and Cook has had 284 yards, four touchdowns, and nine catches for 71 receiving yards in those three games. He's building on consecutive 1,000+ campaigns and Pro Bowl appearances.

The Buffalo Bills were named a suitor for an explosive wideout, but shouldn't be interested in making the move.

"Bills HC Sean McDermott has declared DT Ed Oliver and LB Matt Milano OUT vs. the Saints on Sunday," Joe Buscaglia of The Athletic reports. "RT Spencer Brown and DE AJ Epenesa will be limited at Friday's practice and will be questionable for Sunday."