1. St. Elizabeth Ann Seton, 1774–1821 St. Elizabeth Ann Seton became the first American-born saint in 1975. Born in New York City, she married the love of her life at 19 and welcomed five children.

St. Frances Xavier Cabrini. Credit: Public domain 8. St. Théodore Guérin, 1798–1856 A missionary from France, St. Théodore Guérin founded the Sisters of Providence of Saint Mary-of-the-Woods.

Perhaps the most touching friendship that Ignatius had was with his best friend, St. Francis Xavier. These two were close since college so it must have been heartbreaking to part ways when St. Francis ...