A team of researchers has developed a laboratory model that recapitulates the pathological aggregation of TAR DNA-binding protein 43 (TDP-43), a hallmark of amyotrophic lateral sclerosis (ALS) and ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report 'seeding' this accumulation through fragments of the ...

Serum total TDP-43 concentrations in individual subgroups based on the clinical phenotypes of frontotemporal dementia (FTD), in the total FTD group including all of the phenotypes, and in healthy ...