GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a ...

All Naturally Occurring Mutations in Grow a Garden Mutations are mostly brought on by weather events or limited-time special events taking place within Grow a Garden. This means that while some ...

Background Cholangiocarcinoma (CCA) is a highly lethal malignant tumour with increasing incidence. Current therapies exhibit limited benefits, which urgently demand the identification of novel ...

Lipid droplets (LDs) are dynamic organelles implicated in Parkinson’s disease (PD) pathology, yet their polarity dynamics and therapeutic relevance remain poorly understood. Herein, we rationally ...

The 500-year-old clue got them started, but archaeologists needed more modern georadar techniques to finish the job.

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells. Disruption of this enzyme altered cancer-related pathways and cell ...

Sterols are beneficial plant metabolites with proven human health effects. In rapeseed (Brassica napus), enhancing sterol content could add significant nutritional value to edible oils.

Exhaled breath contains hundreds of volatile organic compounds (VOCs) linked to various biochemical pathways, hence tracking their concentration levels useful for the early detection, substaging, and ...

Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders.