Highlights from Prelude’s efforts to discover and develop selective KAT6A degraders, including preclinical data, demonstrating potential for a differentiated efficacy and safety profile ...

Explore the impact of 3D models in drug discovery and how they enhance predictive insights in pre-clinical research.

New phase 2b/3 trial results with MSD's experimental respiratory syncytial virus (RSV) antibody clesrovimab have fired a shot across the bows of AstraZeneca and Sanofi, currently predicting ...

Autoimmune thyroid disease (AITD) causes cellular damage and alters thyroid gland function by humoral and cell-mediated mechanisms. Cellular damage occurs when sensitized T-lymphocytes and/or ...

In this study, we introduce a novel dual-PROTAC strategy that recruits two distinct E3 ligases, such as KEAP1 and VHL, to cooperatively degrade KRAS(G12D) and Androgen Receptor (AR). Our data ...

Cancer Res (2025) 85 (8_Supplement_1): 1526. VHL loss is a cardinal feature of renal cell carcinoma (RCC), specifically of the clear cell RCC (ccRCC) subtype, and leads to activation of aerobic ...