Department of Physics, TU Dortmund University, Dortmund, Germany We introduce and parameterize a chemomechanical model of microtubule dynamics on the dimer level, which is based on the allosteric ...

These ultrapotent vinblastines display much higher tubulin binding affinities and likely further disrupt the tubulin head-to-tail dimer–dimer interaction by strategic placement of an added rigid, ...

Hinge Bio, Inc. is a privately held development-stage biotechnology company leveraging its proprietary GEM-DIMER™ platform to design and develop therapeutics leading to better treatment outcomes for ...

5-Prime | Diming Out Dimerization What is dimerization? It is a process where two molecules of similar chemical composition come together to form a single polymer known as a dimer. Where does ...

We investigated theoretical conditions whereby tubulin filaments act as photonic crystals with a unit cell consisted of a tubulin dimer. We proposed a model in which each tubulin monomer is an ...

Tubulin isotype families appear to be phylum-specific; in other words, comparison of the amino acid sequences of the various tubulins suggests that in any given phylum, the different β-tubulin ...

Here, we present atomic structures for a protozoan tubulin and microtubule and delineate the architectures of apicomplexan tubulin drug‐binding sites. Based on this information, we rationally designed ...

In molecular biology the term tubulin can refer to the protein superfamily or a specific protein within that family.

Scientists modelled the bending of the tubulin dimer and the whole protofilament, with GTP and GDP bound to them, throughout one millisecond, watching the angle and direction of the curvature and ...

The Rib43a–tubulin interaction leads to an elongated tubulin dimer distance every 2 dimers. In addition, the tubulin lattice structure with missing microtubule inner proteins (MIPs) by sarkosyl ...